Royal Air Force Typhoon fighter aircraft have operated alongside French warplanes in a coordinated attack on an subterranean weapons facility in Syrian territory used by the IS group, according to the UK's MoD.
The location, pinpointed through surveillance, was believed to be containing munitions and bombs, the statement said, and was positioned in mountains just above the historic site of Palmyra in central Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to hit a several approach shafts down to the site... early reports suggest the target was engaged successfully," officials stated.
There was no sign of any harm to civilians in the strike on Saturday evening and each participating jet made a safe return, the ministry further stated.
The Typhoon fighters were assisted by a Voyager refuelling tanker.
Daesh - also known as the so-called Islamic State - imposed militant control over significant areas in Iraq and Syria prior to its 2019 collapse.
"This strike shows the UK's leading role, and resolve to stand shoulder to shoulder with allied nations, to eradicate any resurgence of the terrorist group and their violent and radical beliefs in the area," Britain's Defence Chief the minister remarked.
UK warplanes have conducted surveillance missions over Syria to "deter any attempted comeback" of IS following its routing at the climactic battle in Baghuz in 2019, the MoD reported.
"I extend gratitude to all the members of British forces participating in this operation for their expertise and their valour," he said. "Including them were a great many UK service members stationed over the holidays. This mission, to remove dangerous terrorists who threaten our safety, highlights how our armed forces are prepared to act, throughout the year, keeping Britain secure at home and powerful internationally."
Last December, the United States armed forces carried out what it described as a "large-scale strike" targeting Daesh sites in the country, after an assault claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The UN estimates Islamic State still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.